ACKNOWLEDGEMENT

We wish to express our sincere gratitude and deep regards to our supervisor DHIRAJ SHARMA (Project Associate), IBI Biosolutions for his valuable guidance which has been a constant source of inspiration. We are thankful for his support and generous help in guiding us throughout, despite his busy schedule. His kind nature and strong determination and belief on us helped us to do the work comfortably, overcoming all the problems.

With deep pleasure and gratitude we would like to thank Mr. KUNAL DIXIT, Director, IBI Biosolutions, and Chandigarh. Extreme dedication of Mr. GAURAV GUPTA for his work constantly influenced us to work hard at IBI Biosolutions.

It is a great pleasure for us to acknowledge our heartiest thanks to Dr. JASVEEN DUA, H.o.D., Department of BIOINFORMATICS, GGDSD College, Chandigarh Mrs. SAMRITI DHAWAN, Lecturer, Biotechnology and Dr. ASHIMA PATHAK, Lecturer, Biochemistry for being a great help in understanding our subjects very well and for their kindness and providing necessary facilities to undertake this study.

We are very thankful to Mr. VARINDER KUMAR, Lecturer, Bioinformatics for guiding and helping us all through our course work, for providing us an opportunity to work in such an esteemed Bioinformatics company and to avail the facilities at IBI Biosolutions, Chandigarh.

We express our heartily gratitude to Ms. SHASHI BALA, Lecturer, Bioinformatics for helping us through the nuances of sequence bioinformatics and drug designing which helped us greatly during the development procedure.

We are extremely thankful to Mrs.POONAM SAINI, Mrs. SHAILJA AGNIHOTRI for their guidance, cooperation, incessant encouragement in clarifying the doubts on basic computer skills and kind assistance in the form of knowledge in various computer languages.

Our sincere thanks to Ms. AMARJEET KAUR, LAB MANAGER, GGDSD College who was constantly a help during lab usage and cooperated with us in odd hours also, with smile.

We would also like to thank Dr. PARMILA GUPTA ,Dean of the College of Biotechnology and Life Sciences(Allahabad Agricultural Instt.-Deemed University) for enlighting the path and ouir sincere gratitude to the project advisor Mrs. YASHODHARA VERMA for her encouragment.

Our heartfelt regards to all our teachers since primary education who not only enlightened us with knowledge but also helped us stand and incorporated the much needed moral values and work culture.

We would like to thank Ms. NEERJA, Ms. ANKITA BASANT, our colleagues at IBI who many a time were of great help during exaustive coding sessions and made the task much easier.

Our heartiest thanks goes to our other colleagues at IBI Biosolutions for their cheerful companionship and making our stay at IBI Biosolutions a memorable experience and my classmates at Department of Bioinformatics with whom education was an enjoyable experience.

Our special thanks to our respective familes and all our friends who taught us to work hard and sincerely and were a huge support during our work.

Last but not the least we must be thankful to the ALMIGHTY for His unseen but constant blessings without which every step would have encountered failure.